How Do You Spell ADENYLOSUCCINATE SYNTHASE?

1. Adenylosuccinate synthase is an important enzyme involved in the synthesis of adenosine monophosphate (AMP), a fundamental molecule in cellular metabolism and energy production. This enzyme is primarily responsible for catalyzing the synthesis of adenylosuccinate from inosine monophosphate (IMP) and aspartate.

   Adenylosuccinate synthase belongs to the class of ligases, which are enzymes that are involved in the formation of new chemical bonds. Specifically, this enzyme catalyzes the formation of a bond between the carbon atoms of the aspartate molecule and the carbon atoms of the IMP molecule, resulting in the production of adenylosuccinate.

   The synthesis of adenylosuccinate is a crucial step in the de novo biosynthesis pathway of AMP. This pathway is responsible for the generation of AMP from simple precursor molecules. AMP plays a vital role in cellular energy metabolism, as it acts as a component of adenosine triphosphate (ATP), the major molecule involved in energy storage and transfer in cells.

   Dysfunction or deficiency of adenylosuccinate synthase can lead to various human diseases. For instance, mutations in the gene encoding this enzyme have been associated with an autosomal recessive disorder known as adenylosuccinate lyase deficiency, which is characterized by neurological symptoms such as developmental delay, seizures, and intellectual disability.

   In summary, adenylosuccinate synthase is an enzymatic catalyst that facilitates the formation of adenylosuccinate from IMP and aspartate, playing a crucial role in the biosynthesis of AMP and contributing to cellular energy metabolism.

Common Misspellings for ADENYLOSUCCINATE SYNTHASE

The word "Adenylosuccinate Synthase" has a scientific and technical origin. It is derived from a combination of three main components:

1. Adenylo-: The prefix "adenylo-" is derived from "adenosine", which refers to a molecule containing adenine and ribose. Adenosine is an important nucleoside in DNA and RNA, and it is involved in numerous biological processes.

2. Succinate: Succinate refers to a compound called succinic acid, which is a dicarboxylic acid. The term "succinate" comes from the Latin word "succinum", meaning amber, as it was originally obtained from fossilized tree resin known as amber.

3. Synthase: The suffix "synthase" comes from the word "synthesis", which refers to the process of combining elements or compounds to form a more complex substance.