ANTI HUMAN GLOBULIN COMPLEMENT DEPENDENT CYTOTOXICITY TEST Meaning and
Definition
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The Anti Human Globulin Complement Dependent Cytotoxicity Test (AHG-CDC) is an immunological laboratory technique used to detect antibodies attached to red blood cells (RBCs) and their subsequent activation of the complement system. This test is commonly employed in blood banking and transfusion medicine.
During the AHG-CDC test, RBCs are incubated with patient serum, which may contain antibodies against antigens on the RBCs. Following this, anti-human globulin (AHG), also known as Coombs reagent, is added. The AHG contains antibodies that can bind to human immunoglobulins present on the surface of the patient's RBCs if they have been coated by patient antibodies. Upon which, the complement system is activated by the AHG bound to the patient's RBCs, leading to the formation of membrane attack complexes that damage the RBCs.
The test is read under a microscope, and the degree of RBC damage is assessed. If the RBCs exhibit signs of damage, it suggests that patient antibodies were present and reacted with RBCs, triggering complement activation. This test is primarily used to detect antibodies responsible for immune-mediated hemolytic anemia, autoimmune disorders, and incompatibility between recipient and donor blood during transfusions. It is also employed to determine the presence of antibodies in maternal blood that could potentially cause hemolytic disease of the newborn.
Overall, the AHG-CDC test is a vital tool in diagnosing immune-related blood disorders, identifying incompatible blood products, and ensuring safe transfusion practices.
Common Misspellings for ANTI HUMAN GLOBULIN COMPLEMENT DEPENDENT CYTOTOXICITY TEST
- znti human globulin complement dependent cytotoxicity test
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