BACTERIAL TOPOISOMERASE II Meaning and
Definition
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Bacterial topoisomerase II, also known as DNA gyrase, is a crucial enzyme found in bacteria that plays a fundamental role in DNA replication, transcription, and recombination. It belongs to the type II topoisomerase family and is responsible for regulating the levels of supercoiling in bacterial DNA.
The function of bacterial topoisomerase II involves two primary activities: DNA supercoiling and DNA decatenation. DNA supercoiling includes the ability to introduce negative supercoils into DNA through the controlled breakage and reunion of DNA strands, which helps maintain the compactness and integrity of bacterial DNA. On the other hand, DNA decatenation involves resolving intertwined and knotted DNA structures that arise during DNA replication.
The catalytic mechanism of this enzyme involves a series of ATP-dependent reactions. ATP hydrolysis provides the energy required for the enzyme to break and rejoin DNA strands. Bacterial topoisomerase II achieves this by forming a covalent intermediate with DNA, cleaving both strands of the DNA duplex and passing one duplex through the other before resealing the DNA strands.
Inhibition of bacterial topoisomerase II is a target for various antibiotics, as it disrupts the essential functions of bacterial DNA metabolism and effectively inhibits bacterial growth and proliferation. Therefore, studying bacterial topoisomerase II and its mechanism of action is crucial for the development of antimicrobial agents and understanding the molecular basis of bacterial resistance to antibiotics.
Common Misspellings for BACTERIAL TOPOISOMERASE II
- vacterial topoisomerase ii
- nacterial topoisomerase ii
- hacterial topoisomerase ii
- gacterial topoisomerase ii
- bzcterial topoisomerase ii
- bscterial topoisomerase ii
- bwcterial topoisomerase ii
- bqcterial topoisomerase ii
- baxterial topoisomerase ii
- bavterial topoisomerase ii
- bafterial topoisomerase ii
- badterial topoisomerase ii
- bacrerial topoisomerase ii
- bacferial topoisomerase ii
- bacgerial topoisomerase ii
- bacyerial topoisomerase ii
- bac6erial topoisomerase ii
- bac5erial topoisomerase ii
- bactwrial topoisomerase ii
- bactsrial topoisomerase ii
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