BETA N ACETYLGLUCOSAMINIDASE Meaning and
Definition
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Beta N-acetylglucosaminidase is a hydrolase enzyme that belongs to the glycosidase family and is involved in the breakdown of complex carbohydrates. It is primarily found in lysosomes and is responsible for cleaving N-acetylglucosamine (GlcNAc) residues from oligosaccharides and glycoconjugates. This enzyme plays a crucial role in various physiological processes such as lysosomal degradation, recycling of complex carbohydrates, and cellular signaling.
Beta N-acetylglucosaminidase is commonly abbreviated as β-NAG or β-hexosaminidase. It acts specifically on the β-1,4 glycosidic linkages between GlcNAc residues, releasing GlcNAc monomers. This process is essential for the generation of free GlcNAc, which can be utilized for energy production or converted into other useful molecules in the cell.
Deficiencies in β-NAG activity have been associated with various lysosomal storage disorders, such as Tay-Sachs disease and Sandhoff disease. These disorders result in the accumulation of GlcNAc-containing substrates within lysosomes, leading to cell dysfunction and organ damage.
Measurement of β-NAG activity in biological samples is used as a diagnostic tool for certain lysosomal storage diseases. It can be quantified using specific enzymatic assays, typically based on the hydrolysis of synthetic substrates by β-NAG. Additionally, the activity level of β-N-acetylglucosaminidase can serve as a biomarker for monitoring disease progression and evaluating the effectiveness of therapeutic interventions.
Common Misspellings for BETA N ACETYLGLUCOSAMINIDASE
- veta n acetylglucosaminidase
- neta n acetylglucosaminidase
- heta n acetylglucosaminidase
- geta n acetylglucosaminidase
- bwta n acetylglucosaminidase
- bsta n acetylglucosaminidase
- bdta n acetylglucosaminidase
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- b4ta n acetylglucosaminidase
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- bera n acetylglucosaminidase
- befa n acetylglucosaminidase
- bega n acetylglucosaminidase
- beya n acetylglucosaminidase
- be6a n acetylglucosaminidase
- be5a n acetylglucosaminidase
- betz n acetylglucosaminidase
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- betw n acetylglucosaminidase
- betq n acetylglucosaminidase
Similar spelling word for BETA N ACETYLGLUCOSAMINIDASE
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