COMPLEMENTARITY DETERMINING REGIONS Meaning and
Definition
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Complementarity Determining Regions (CDRs) are specific regions within the variable domain of antibody molecules that play a crucial role in the immune response. Antibodies, also known as immunoglobulins, are Y-shaped proteins produced by B lymphocytes (B cells) in response to the presence of foreign substances called antigens.
The variable domain of an antibody molecule consists of six CDRs, three on each of the two heavy and light chains. These CDRs are highly diverse and are responsible for recognizing and binding to specific antigens. Each CDR contains a unique amino acid sequence, allowing for the diverse array of antigens that can be recognized by antibodies.
CDRs are also referred to as hypervariable regions due to their high variability. They are made up of loops that extend from the antibody structure, forming the antigen-binding site. The CDRs directly interact with the antigen, forming a lock-and-key-like mechanism to mediate antigen recognition and binding. The antigen-antibody interaction triggers a cascade of immune responses, leading to the elimination of the harmful antigens.
Understanding the structure and function of CDRs is essential for the development of therapeutic antibodies, as well as for the design and engineering of novel antibodies with desired antigen specificities. By manipulating the amino acid sequences of CDRs, scientists can create antibodies with enhanced affinity and specificity for particular antigens, opening avenues for targeted therapies and diagnostics in various diseases, including cancer, infections, and autoimmune disorders.
Common Misspellings for COMPLEMENTARITY DETERMINING REGIONS
- xomplementarity determining regions
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- conplementarity determining regions
- cokplementarity determining regions
- cojplementarity determining regions
- comolementarity determining regions
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- comppementarity determining regions
- compoementarity determining regions
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