DEOXYCYTIDINE MONOPHOSPHATE DEAMINASE Meaning and
Definition
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Deoxycytidine monophosphate deaminase (dCMPD) is an enzyme that plays a crucial role in nucleotide metabolism. It is also known as deoxycytidylate deaminase or dCMP deaminase. This enzyme is involved in the conversion of deoxycytidine monophosphate (dCMP) into deoxyuridine monophosphate (dUMP), which is a key step in the biosynthesis of thymidine, an essential component of DNA.
The primary function of dCMPD is to remove the amino group (NH2) from the cytosine base of dCMP, replacing it with oxygen. This deamination reaction is essential to maintain the balance of nucleotide pools in the cell and to prevent the accumulation of excessive dCMP. Excessive levels of dCMP can lead to increased DNA damage and genomic instability.
The activity of dCMPD is regulated by feedback inhibition from dUMP, ensuring a delicate balance between the synthesis of dUMP and the elimination of dCMP. Inhibition of dCMPD by dUMP prevents the excessive conversion of dCMP and allows for the production of an adequate amount of dTMP (thymidine monophosphate) for DNA synthesis.
Deficiencies or mutations in dCMPD can lead to altered nucleotide metabolism, resulting in various disorders such as megaloblastic anemia and hereditary orotic aciduria. These conditions are characterized by abnormal DNA synthesis and impaired red blood cell production.
In summary, Deoxycytidine monophosphate deaminase is an essential enzyme involved in nucleotide metabolism that converts dCMP to dUMP, contributing to the production of thymidine for DNA synthesis while maintaining the balance of nucleotide pools in the cell.
Common Misspellings for DEOXYCYTIDINE MONOPHOSPHATE DEAMINASE
- seoxycytidine monophosphate deaminase
- xeoxycytidine monophosphate deaminase
- ceoxycytidine monophosphate deaminase
- feoxycytidine monophosphate deaminase
- reoxycytidine monophosphate deaminase
- eeoxycytidine monophosphate deaminase
- dwoxycytidine monophosphate deaminase
- dsoxycytidine monophosphate deaminase
- ddoxycytidine monophosphate deaminase
- droxycytidine monophosphate deaminase
- d4oxycytidine monophosphate deaminase
- d3oxycytidine monophosphate deaminase
- deixycytidine monophosphate deaminase
- dekxycytidine monophosphate deaminase
- delxycytidine monophosphate deaminase
- depxycytidine monophosphate deaminase
- de0xycytidine monophosphate deaminase
- de9xycytidine monophosphate deaminase
- deozycytidine monophosphate deaminase
- deocycytidine monophosphate deaminase
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