DT DIAPHORASE Meaning and
Definition
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DT diaphorase, also known as NAD(P)H:quinone oxidoreductase 1 (NQO1), is a cytosolic enzyme that is involved in the reduction of quinones and quinone-like compounds. This enzyme plays a significant role in the detoxification and metabolism of various xenobiotics and endogenous compounds within the body.
DT diaphorase is a flavoprotein, containing a flavin adenine dinucleotide (FAD) cofactor, which is required for its catalytic activity. It catalyzes the two-electron reduction of quinones, including a wide range of exogenous and endogenous compounds, by utilizing reducing equivalents derived from the cofactor NAD(P)H.
The reduction reaction catalyzed by DT diaphorase is essential in maintaining the redox balance within cells and plays a vital role in the protection against oxidative stress. It prevents the formation of toxic reactive oxygen species (ROS) by participating in the detoxification process, converting reactive quinones to less reactive hydroquinones.
Furthermore, DT diaphorase has been identified as an important regulator in the activation and sensitivity of certain anticancer drugs, such as quinones and bioreductive agents. Its high expression in some tumor cells has been associated with increased resistance to therapy.
Overall, DT diaphorase is an essential enzyme involved in various physiological and pharmacological processes. Its ability to catalyze the two-electron reduction of quinones and quinone-like compounds contributes to the detoxification of harmful substances and maintenance of cellular redox balance, making it a significant target for therapeutic interventions and drug design.
Common Misspellings for DT DIAPHORASE
- st diaphorase
- xt diaphorase
- ct diaphorase
- ft diaphorase
- rt diaphorase
- et diaphorase
- dr diaphorase
- df diaphorase
- dg diaphorase
- dy diaphorase
- d6 diaphorase
- d5 diaphorase
- dt siaphorase
- dt xiaphorase
- dt ciaphorase
- dt fiaphorase
- dt riaphorase
- dt eiaphorase
- dt duaphorase
- dt djaphorase
Etymology of DT DIAPHORASE
The word "DT Diaphorase" does not have a specific etymology as it is a scientific term that is not derived from a particular language or historical origin.
However, the term "diaphorase" itself comes from the Greek word "diaphoros", meaning "distinguished" or "different". In the context of biochemistry and enzymology, diaphorase refers to a class of enzymes involved in metabolic pathways and electron transfer processes.
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