EDRF SYNTHASE Meaning and
Definition
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EDRF Synthase, also known as endothelial nitric oxide synthase (eNOS), is a key enzyme involved in the production of nitric oxide (NO) within the endothelial cells lining blood vessels. Nitric oxide is a potent vasodilator which plays a critical role in regulating vascular tone and maintaining cardiovascular homeostasis.
The synthesis of nitric oxide occurs through the activity of EDRF Synthase, which catalyzes the conversion of the amino acid L-arginine into L-citrulline, simultaneously producing a molecule of NO. This enzymatic reaction is dependent on calcium and various cofactors, such as flavin mononucleotide (FMN), flavin adenine dinucleotide (FAD), and tetrahydrobiopterin (BH4).
EDRF Synthase is primarily expressed in endothelial cells, where it regulates vascular smooth muscle relaxation, platelet aggregation, and cell adhesion. Nitric oxide produced by EDRF Synthase acts as a signaling molecule, modulating various physiological processes, including blood pressure regulation, inflammation, immune response, and angiogenesis.
Dysfunction or impaired activity of EDRF Synthase can lead to endothelial dysfunction, characterized by reduced nitric oxide production. This condition is implicated in the pathogenesis of numerous cardiovascular diseases, including hypertension, atherosclerosis, and coronary artery disease.
Pharmacological agents that enhance the activity of EDRF Synthase, such as certain calcium channel blockers, statins, and ACE inhibitors, are commonly used in the treatment of cardiovascular disorders to restore normal endothelial function and improve vascular health.
Common Misspellings for EDRF SYNTHASE
- wdrf synthase
- sdrf synthase
- ddrf synthase
- rdrf synthase
- 4drf synthase
- 3drf synthase
- esrf synthase
- exrf synthase
- ecrf synthase
- efrf synthase
- errf synthase
- eerf synthase
- edef synthase
- eddf synthase
- edff synthase
- edtf synthase
- ed5f synthase
- ed4f synthase
- edrd synthase
- edrc synthase
Etymology of EDRF SYNTHASE
The word "EDRF Synthase" is formed by combining two terms: "EDRF" and "synthase".
1. EDRF: EDRF stands for Endothelium-Derived Relaxing Factor. It is a term that was used to describe a substance released by the endothelium (the inner lining of blood vessels) that was responsible for the relaxation of smooth muscles surrounding blood vessels. Eventually, it was discovered that EDRF is primarily Nitric Oxide (NO), a signaling molecule involved in various physiological processes.
2. Synthase: The suffix "-synthase" is derived from the word "synthesize", which means to create or produce. In biochemistry, "synthase" is used to designate an enzyme that catalyzes the synthesis or production of a specific molecule.
