FC RECEPTORS Meaning and
Definition
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Fc receptors, short for Fragment crystallizable receptors, are a group of cell surface receptors found on various immune cells, primarily on B cells, natural killer cells, macrophages, and neutrophils. These receptors play a crucial role in the immune response by recognizing and binding to the constant (Fc) regions of antibodies, specifically the Fc region of immunoglobulin G (IgG), IgE, and IgM antibodies.
The binding of Fc receptors to the Fc region of antibodies triggers a variety of immune functions, including phagocytosis, antibody-dependent cellular cytotoxicity (ADCC), degranulation, and cytokine release. These functions help to eliminate pathogens, activate the complement system, recruit other immune cells, and modulate the immune response.
There are several types of Fc receptors, categorized based on their structure and the antibody isotypes they bind. The most common Fc receptor is Fcγ receptor (FcγR), which is involved in the recognition of IgG antibodies. Fcγ receptors exist in different forms, such as FcγRI (CD64), FcγRII (CD32), and FcγRIII (CD16), each with distinct binding affinities, distribution, and functions.
Fc receptors are critical in antibody-based immunotherapies, such as monoclonal antibodies, as they enhance the efficiency and effectiveness of these therapies by mediating antibody-dependent cell-mediated cytotoxicity (ADCC) and phagocytosis. Understanding the role and function of Fc receptors is essential in the development of targeted therapies for various diseases, including cancer, autoimmune disorders, and infectious diseases.
Common Misspellings for FC RECEPTORS
- dc receptors
- vc receptors
- gc receptors
- tc receptors
- rc receptors
- fx receptors
- fv receptors
- ff receptors
- fd receptors
- fc eeceptors
- fc deceptors
- fc feceptors
- fc teceptors
- fc 5eceptors
- fc 4eceptors
- fc rwceptors
- fc rsceptors
- fc rdceptors
- fc rrceptors
- fc r4ceptors
Etymology of FC RECEPTORS
The word "Fc receptors" stands for "fragment crystallizable receptors". Let's break down the etymology of this term:
1. Fragment: In this context, "fragment" refers to a segment or portion of an antibody molecule. Antibodies consist of two main parts: a fragment antigen-binding (Fab) region and a fragment crystallizable (Fc) region. The Fab region binds to specific antigens, while the Fc region interacts with different cells or molecules through Fc receptors.
2. Crystallizable: The term "crystallizable" describes the property of the Fc region of antibodies to crystallize. This means that under certain conditions, antibodies can form crystals, allowing for their structural analysis. The Fc region contains a constant region that is the same for all antibodies of a particular class, which is important for binding to Fc receptors.
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