FREE BASE Meaning and
Definition
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Free base refers to a form of a compound that is in its pure, uncharged state. It is a term commonly used in chemistry and pharmacology to describe the unprotonated, or non-salt form, of a compound. This state is typically achieved by removing any charged groups or counterions that may be attached to the molecule. Free base compounds are often found in the form of solids, liquids, or gases, and they can vary widely in their physical properties.
In pharmacology, free base drugs are typically more lipid soluble and can cross cell membranes more easily than their charged counterparts. This characteristic can be advantageous for drug delivery as it can enhance the absorption and distribution of the drug within the body. To create a free base from a medicinal compound, different techniques such as chemical extractions or removal of salt groups may be employed.
The term "free base" is also commonly associated with recreational drugs, particularly in the context of illegal drug use. In this context, free base refers to the alkaloid form of drugs, such as cocaine or amphetamines, which are transformed into a base form to enhance its potency, volatility, or ease of smoking. This is often achieved by chemically manipulating the drug with a strong alkali, such as ammonia or sodium bicarbonate, resulting in a highly-purified form suitable for smoking. This practice is often associated with increased addiction potential and severe health risks.
Common Misspellings for FREE BASE
Etymology of FREE BASE
The word "freebase" is derived from a combination of two terms. The first part, "free", refers to the fact that the drug being referred to is in its "free form" or uncharged state, which increases its potency and bioavailability. The second part, "base", refers to the alkaline substance used to deprotonate or remove acidic protons from the drug molecule, usually using ammonia or a similar compound. This process of converting a drug's hydrochloride or other salt form into a free base form was a common practice in the illicit drug subculture during the early 1960s. The term "freebase" became widely known when it was associated with the smoking of cocaine.
Similar spelling word for FREE BASE
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