GELATINASE B Meaning and
Definition
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Gelatinase B, also known as matrix metalloproteinase-9 (MMP-9), is an enzyme belonging to the matrix metalloproteinase family. It is involved in the degradation and remodeling of extracellular matrix (ECM) components in various physiological and pathological processes. Gelatinase B specifically targets collagen type IV, collagen type V, and elastin within the ECM.
The enzyme is synthesized as an inactive zymogen, pro-gelatinase B, which is activated through proteolytic cleavage. Once activated, gelatinase B exhibits proteolytic activity towards a wide range of substrates, including various matrix components and non-matrix proteins. It can cleave and degrade ECM proteins, leading to tissue remodeling, wound healing, and tissue repair.
Gelatinase B plays a crucial role in many pathological conditions, such as inflammation, cancer metastasis, and tissue damage. Differential regulation of its expression and activity is observed in different diseases, highlighting its involvement in disease progression.
Measurement of gelatinase B activity or levels is often conducted through laboratory techniques, including gelatin zymography, immunohistochemistry, or enzyme-linked immunosorbent assays (ELISA). These quantification methods help in evaluating the enzyme's activity and its potential role in disease development or response to treatment.
Understanding gelatinase B's function and regulation is important for developing therapeutic strategies targeting its activity. Inhibitors of gelatinase B have been investigated for their potential use in treating diseases associated with excessive ECM degradation or pathological tissue remodeling, such as rheumatoid arthritis or cancer metastasis.
Common Misspellings for GELATINASE B
- felatinase b
- velatinase b
- belatinase b
- helatinase b
- yelatinase b
- telatinase b
- gwlatinase b
- gslatinase b
- gdlatinase b
- grlatinase b
- g4latinase b
- g3latinase b
- gekatinase b
- gepatinase b
- geoatinase b
- gelztinase b
- gelstinase b
- gelwtinase b
- gelqtinase b
- gelarinase b
Etymology of GELATINASE B
The word "Gelatinase B" consists of two main components: "gelatinase" and "B".
1. Gelatinase: The term "gelatinase" is derived from the word "gelatin", which refers to a protein formed by partial hydrolysis of collagen, extracted from animal skin and bones. Gelatin is usually used in food and medical applications due to its gelatinous properties. The suffix "-ase" in "gelatinase" indicates an enzyme that breaks down or digests gelatin.
2. B: The letter "B" is used as a suffix to distinguish between different forms or subtypes of an enzyme. In the case of "Gelatinase B", it signifies a specific variant or isoform of the gelatinase enzyme. The alphabet designation (A, B, C, etc.
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