How Do You Spell GRANULES OF NISSL?

1. Granules of Nissl, also known as Nissl bodies or Nissl substance, are cellular structures found within the cytoplasm of neurons. They were first discovered and named by German neuropathologist and psychiatrist Franz Nissl in the late 19th century.

   Granules of Nissl are composed of ribosomes, which are the cellular organelles responsible for protein synthesis. These granules are particularly dense in neurons, where they are found predominantly in the cell body or soma, as well as in dendrites and proximal regions of the axon. They stain strongly with basic dyes, such as methylene blue, enabling their visualization under a microscope.

   The function of granules of Nissl is directly linked to their composition of ribosomes. These ribosomes play a crucial role in the production of proteins necessary for neuronal structure and function. They engage in protein synthesis by translating the genetic information carried by messenger RNA (mRNA) into functional proteins.

   The presence of well-developed granules of Nissl in a neuron typically indicates active protein synthesis and high metabolic activity. Conversely, conditions or events that disrupt protein synthesis can cause a reduction or disintegration of these granules. This can occur in neuropathological conditions such as Alzheimer's disease, Parkinson's disease, and certain types of viral infections.

   Overall, the granules of Nissl are important cellular components that contribute to the normal functioning and maintenance of neurons through their role in protein synthesis.

Common Misspellings for GRANULES OF NISSL