HLA D ANTIGENS Meaning and
Definition
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HLA D antigens, also known as human leukocyte antigen D antigens, are proteins found on the surface of cells in the immune system that play a crucial role in immunological responses. They are a subset of HLA proteins, which are encoded by the major histocompatibility complex (MHC) genes located on chromosome 6 in humans.
HLA D antigens are primarily concerned with presenting foreign antigens to specialized immune cells called T lymphocytes. These antigens are presented on the surface of antigen-presenting cells, such as macrophages, dendritic cells, and B cells. When a pathogen or foreign substance enters the body, it is processed by these antigen-presenting cells and then presented to specific T cells.
HLA D antigens are classified into two groups: HLA-DR and HLA-DQ. HLA-DR antigens are responsible for presenting antigens to helper T cells, which then stimulate immune responses against the foreign substance. HLA-DQ antigens, on the other hand, present antigens to both helper T cells and cytotoxic T cells, aiding in the activation of the immune system against infected or cancerous cells.
These HLA D antigens are highly polymorphic, meaning they have multiple variations within the population. This diversity allows individuals to respond to a wide range of pathogens, as not all antigens can be presented by every HLA D variant. Incompatibility or mismatch between the HLA D antigens of organ donors and recipients is a significant consideration in transplantation procedures, as it can result in rejection of the transplanted organ.
Common Misspellings for HLA D ANTIGENS
- hla aq antigens
- gla d antigens
- bla d antigens
- nla d antigens
- jla d antigens
- ula d antigens
- yla d antigens
- hka d antigens
- hpa d antigens
- hoa d antigens
- hlz d antigens
- hls d antigens
- hlw d antigens
- hlq d antigens
- hla d zntigens
- hla d sntigens
- hla d wntigens
- hla d qntigens
- hla d abtigens
- hla d amtigens
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