JOBS SYNDROME Meaning and
Definition
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Job's syndrome, also known as hyperimmunoglobulin E syndrome (HIES), is a rare genetic disorder characterized by recurrent infections and various immune system abnormalities. It is named after the biblical character Job because of the severe suffering associated with the condition.
The primary feature of Job's syndrome is a weakened immune system, resulting in recurrent and severe bacterial and fungal infections of the skin, lungs, and other organs. Additionally, affected individuals often exhibit an excessive production of immunoglobulin E (IgE), a type of antibody involved in allergic reactions. This overproduction of IgE can lead to a range of allergic symptoms, such as asthma, eczema, and food allergies.
The syndrome commonly presents with distinctive physical features including a characteristic facial appearance, such as a prominent forehead, broad nose, and deep-set eyes. Dental abnormalities, skeletal abnormalities, and abnormalities in connective tissue are also frequently observed in individuals with Job's syndrome.
Job's syndrome is caused by mutations in the STAT3 gene, which encodes a protein necessary for signaling in immune cells. These mutations disrupt the regulation of immune responses, leading to the dysregulation observed in individuals with the syndrome.
Treatment for Job's syndrome focuses on managing and preventing infections, often involving the long-term use of antibiotics and antifungal medications. Additionally, close monitoring of IgE levels and prompt treatment of allergic symptoms is important in managing the condition. Genetic counseling may be beneficial for affected individuals and their families to understand the inheritance pattern and risks associated with the syndrome.
Common Misspellings for JOBS SYNDROME
- hobs syndrome
- nobs syndrome
- mobs syndrome
- kobs syndrome
- iobs syndrome
- uobs syndrome
- jibs syndrome
- jkbs syndrome
- jlbs syndrome
- jpbs syndrome
- j0bs syndrome
- j9bs syndrome
- jovs syndrome
- jons syndrome
- johs syndrome
- jogs syndrome
- joba syndrome
- jobz syndrome
- jobx syndrome
- jobd syndrome
Etymology of JOBS SYNDROME
The term "Job's syndrome" is named after Dr. Albert Job, a French immunologist who first described the rare genetic disorder in 1966. The condition, formally known as Hyper-IgE Syndrome, is characterized by frequent bacterial and fungal infections, dermatitis, and high levels of immunoglobulin E (IgE) in the blood. Dr. Job's research into this syndrome and subsequent publications led to the use of his name in reference to the disorder.
