NADH FERRIHEMOGLOBIN REDUCTASE Meaning and
Definition
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NADH Ferrihemoglobin Reductase, also known as methemoglobin reductase or cytochrome b5 reductase, is an enzyme that plays a vital role in the cleansing of the blood by reducing methemoglobin back to functional hemoglobin. Methemoglobin is a form of hemoglobin that cannot bind oxygen, rendering it unable to transport oxygen to tissues effectively.
NADH Ferrihemoglobin Reductase is responsible for the conversion of methemoglobin to hemoglobin by transferring electrons from NADH, which acts as a coenzyme, to the iron ion in the heme group of methemoglobin. This process is crucial because high levels of methemoglobin can lead to a condition called methemoglobinemia, characterized by a reduced capacity to deliver oxygen to tissues, resulting in cyanosis (a bluish discoloration of the skin).
The enzyme is composed of multiple subunits, including cytochrome b5, flavin mononucleotide (FMN), and flavin adenine dinucleotide (FAD). These subunits work together to facilitate the transfer of electrons and the reduction of methemoglobin. The enzyme is primarily found in red blood cells, where it helps maintain the balance between methemoglobin and functional hemoglobin to ensure proper oxygen delivery.
Understanding the function and regulation of NADH Ferrihemoglobin Reductase is crucial in diagnosing and treating disorders related to methemoglobin levels. Deficiencies or mutations in the enzyme can lead to disorders such as hereditary methemoglobinemia, which can cause symptoms such as fatigue, shortness of breath, and poor oxygenation. Pharmacological interventions that either activate or inhibit NADH Ferrihemoglobin Reductase may also have therapeutic implications in managing
Common Misspellings for NADH FERRIHEMOGLOBIN REDUCTASE
- badh ferrihemoglobin reductase
- madh ferrihemoglobin reductase
- jadh ferrihemoglobin reductase
- hadh ferrihemoglobin reductase
- nzdh ferrihemoglobin reductase
- nsdh ferrihemoglobin reductase
- nwdh ferrihemoglobin reductase
- nqdh ferrihemoglobin reductase
- nash ferrihemoglobin reductase
- naxh ferrihemoglobin reductase
- nach ferrihemoglobin reductase
- nafh ferrihemoglobin reductase
- narh ferrihemoglobin reductase
- naeh ferrihemoglobin reductase
- nadg ferrihemoglobin reductase
- nadb ferrihemoglobin reductase
- nadn ferrihemoglobin reductase
- nadj ferrihemoglobin reductase
- nadu ferrihemoglobin reductase
- nady ferrihemoglobin reductase
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