NISSL GRANULE Meaning and
Definition
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Nissl granules, also known as Nissl bodies or Nissl substance, refer to collections of rough endoplasmic reticulum found in the cell body of neurons. They are named after the German neurologist and psychiatrist, Franz Nissl, who first identified and described these structures in the late 19th century.
These granules are composed of ribosomes, which are responsible for protein synthesis within the cell. They are densely packed and can be visualized under a microscope as dark-staining clusters or dots within the cytoplasm of neurons. Nissl granules are particularly abundant in regions of the neuron that have high metabolic activity, such as the dendrites and cell body, where they play a crucial role in protein production to support cellular functions.
The presence of Nissl granules can serve as an indicator of neuronal health and activity. Changes in the size, shape, or density of these granules may indicate pathological conditions like neuronal degeneration or cell death. As such, staining for Nissl substance has been widely used in histology and neuropathology to identify and characterize various neurodegenerative diseases, such as Alzheimer's and Parkinson's.
In summary, Nissl granules are ribosome-rich structures found in the cytoplasm of neurons involved in protein synthesis. They are notable for their distinct appearance under a microscope and serve as essential components for maintaining the integrity and functionality of neurons.
Common Misspellings for NISSL GRANULE
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Etymology of NISSL GRANULE
The word "Nissl granule" is named after Franz Nissl, a German neuropathologist. These granules were first described by Nissl in the late 19th century as dense clusters of granular structures in the cytoplasm of neurons. They are primarily composed of rough endoplasmic reticulum and represent sites of protein synthesis within the neuron. Since the discovery and characterization of Nissl granules by Franz Nissl, they have become an important histological marker for studying the structure and function of neurons.
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