Nonsteroidal antirheumatic agents, commonly abbreviated as NSAIDs, are a class of medications widely used in the treatment of rheumatic conditions, including inflammatory disorders and chronic pain.
These drugs are called nonsteroidal as they do not contain corticosteroids, which are synthetic steroidal compounds that possess anti-inflammatory properties. Instead, nonsteroidal antirheumatic agents work by inhibiting the production of certain enzymes known as cyclooxygenases (COX), which play a crucial role in the formation of prostaglandins—a group of chemicals involved in inflammation, pain, and fever.
By blocking COX enzymes, NSAIDs effectively reduce the production of prostaglandins, thus alleviating inflammation, swelling, and pain associated with rheumatic conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. Additionally, these agents may also help in reducing fever.
Nonsteroidal antirheumatic agents come in various forms, including tablets, capsules, creams, gels, and patches. Some of the commonly prescribed NSAIDs include ibuprofen, naproxen, diclofenac, and celecoxib. These medications can be obtained over-the-counter or by prescription, depending on their strength and dosage.
While nonsteroidal antirheumatic agents are generally effective in managing rheumatic symptoms, it is important to note that they can also be associated with certain adverse effects. These may include gastrointestinal complications such as stomach ulcers and bleeding, kidney problems, and cardiovascular risks. Therefore, it is crucial for individuals using NSAIDs to follow their healthcare provider's instructions and consult with them regarding any concerns or side effects.
