PDGFRB Meaning and
Definition
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PDGFRB is an acronym for Platelet-Derived Growth Factor Receptor Beta. It represents a specific gene called PDGFRB that codes for a receptor protein present on the surface of cells. This gene belongs to a family of tyrosine kinase receptors and is a member of the platelet-derived growth factor receptor family.
The PDGFRB gene is responsible for providing instructions for the production of a protein receptor that binds to a specific molecule known as platelet-derived growth factor (PDGF). This receptor protein plays a crucial role in various biological processes, including cell growth, development, and division. It functions as a transmembrane receptor, meaning it spans the cell membrane, and upon activation by the binding of PDGF, it triggers a series of biochemical signals within the cell that regulate these processes.
Abnormalities or mutations in the PDGFRB gene have been associated with certain medical conditions, including different types of cancer, such as chronic myelomonocytic leukemia. These mutations can lead to overexpression or dysregulation of the PDGFRB receptor, resulting in uncontrolled cell growth and division.
In summary, PDGFRB is a gene that codes for a protein receptor involved in cell growth and development, particularly responding to platelet-derived growth factor. Its function is crucial in maintaining normal cellular processes, and any abnormalities in this gene may contribute to the development of specific diseases, including certain types of cancer.
Common Misspellings for PDGFRB
