How Do You Spell PREPHENATE DEHYDROGENASE?

1. Prephenate dehydrogenase is an enzyme that plays a crucial role in the metabolic pathway of aromatic amino acid biosynthesis, particularly in plants, bacteria, and fungi. It catalyzes the conversion of prephenate, an intermediate compound in this pathway, to 4-hydroxyphenylpyruvate.

   The enzyme prephenate dehydrogenase belongs to the family of oxidoreductases, specifically those acting on the CH or CH2 groups of donor molecules with NAD+ or NADP+ as acceptor. It utilizes nicotinamide adenine dinucleotide phosphate (NADP+) as a coenzyme in the reaction. Through an oxidation-reduction process, the enzyme removes a hydrogen atom from the carbon adjacent to the carboxyl group of prephenate, leading to the formation of 4-hydroxyphenylpyruvate. This reaction is a key step in the conversion of aromatic amino acid precursors, such as phenylalanine and tyrosine, in the metabolic pathway.

   Prephenate dehydrogenase is essential for the synthesis of important metabolites and secondary metabolites in living organisms, including plant-derived compounds with various biological activities and medicinal properties. The enzyme's activity can be regulated by other molecules, such as the concentration of cofactors or intermediates in the pathway, as well as the presence of inhibitors or activators. Understanding the biochemical properties and regulation of prephenate dehydrogenase is important for elucidating the mechanisms of aromatic amino acid biosynthesis and for potential applications in agriculture, biotechnology, and pharmaceutical research.

Common Misspellings for PREPHENATE DEHYDROGENASE

The word "prephenate dehydrogenase" is composed of two main components: "prephenate" and "dehydrogenase".

1. Prephenate: The term "prephenate" stems from the chemical compound called "prephenic acid". Prephenic acid is an intermediate compound formed during the biosynthesis of aromatic amino acids such as phenylalanine, tyrosine, and tryptophan. It is derived from the shikimate pathway, which occurs in plants, fungi, and bacteria. The term "prephenate" was coined in relation to this compound.

2. Dehydrogenase: The word "dehydrogenase" is a compound term formed by combining "dehydro" and "genase". "Dehydro" is derived from the Greek prefix "de-" meaning "removal" or "loss", indicating the removal of hydrogen atoms.