PUROMYCIN DIHYDROCHLORIDE Meaning and
Definition
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Puromycin dihydrochloride is a chemical compound that belongs to the class of antibiotics called aminonucleosides. It is derived from Streptomyces alboniger and is primarily used as a selective inhibitor of protein synthesis.
This antibiotic works by binding to the 50S subunit of the bacterial ribosome, which hinders the elongation step of protein synthesis. By interrupting the formation of peptide bonds, puromycin dihydrochloride effectively prevents the completion of protein synthesis and inhibits bacterial growth.
Puromycin dihydrochloride is widely used in molecular biology and cell culture studies due to its ability to selectively kill cells that possess a puromycin resistance gene. Therefore, it is commonly employed for the selection and maintenance of cells that have been genetically modified to express this resistance gene.
In cell culture experiments, puromycin dihydrochloride is often included in the growth media to eliminate unwanted cells or select for specific cell populations. Its high potency and rapid action make it particularly useful for gene expression studies, where it is necessary to introduce foreign genetic material into cells and subsequently identify and isolate the successfully transformed cells.
It is worth noting that puromycin dihydrochloride is highly toxic to mammalian cells at higher concentrations and should be handled and used with caution, following appropriate safety protocols. Its pharmacological properties and selectivity make it a valuable tool in scientific research and various applications in the fields of molecular biology and cell culture.
Common Misspellings for PUROMYCIN DIHYDROCHLORIDE
- ouromycin dihydrochloride
- luromycin dihydrochloride
- -uromycin dihydrochloride
- 0uromycin dihydrochloride
- pyromycin dihydrochloride
- phromycin dihydrochloride
- pjromycin dihydrochloride
- piromycin dihydrochloride
- p8romycin dihydrochloride
- p7romycin dihydrochloride
- pueomycin dihydrochloride
- pudomycin dihydrochloride
- pufomycin dihydrochloride
- putomycin dihydrochloride
- pu5omycin dihydrochloride
- pu4omycin dihydrochloride
- purimycin dihydrochloride
- purkmycin dihydrochloride
- purlmycin dihydrochloride
- purpmycin dihydrochloride
Etymology of PUROMYCIN DIHYDROCHLORIDE
The word "Puromycin" is based on the Latin term "purus", which means "pure". It is combined with "mycin", which is a suffix used for certain types of antibiotics. "Dihydrochloride" refers to the chemical compound containing two hydrochloride groups. Therefore, the term "Puromycin Dihydrochloride" implies a pure antibiotic compound with two hydrochloride groups.
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