SUBSTANCE P RECEPTORS Meaning and
Definition
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Substance P receptors, also known as neurokinin-1 receptors (NK1 receptors), are a type of cell membrane protein that play a key role in the transmission of pain signals in the body. Substance P is a neuropeptide, which means it is a type of signaling molecule that functions as a neurotransmitter or neuromodulator.
When released by nerve cells (neurons), substance P can bind to and activate its corresponding receptors, the substance P receptors, which are predominantly found in the central and peripheral nervous systems. This binding initiates a series of biochemical events within the neurons, leading to the transmission of pain signals from the site of injury or inflammation to the brain.
Substance P receptors are G protein-coupled receptors, meaning that they work by interacting with specialized proteins called G proteins on the inside of the cell membrane. This interaction results in the activation of multiple intracellular signaling pathways, such as the protein kinase C pathway, which ultimately leads to a heightened sensitivity to pain and the perception of pain.
Due to their involvement in pain transmission, substance P receptors have become attractive targets for the development of analgesic drugs. By blocking or modulating the activity of these receptors, it is possible to interfere with the transmission of pain signals, offering potential therapeutic benefits for conditions such as chronic pain, migraine, and other neurological disorders.
Common Misspellings for SUBSTANCE P RECEPTORS
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