TUMOR ESCAPE Meaning and
Definition
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Tumor escape refers to the phenomenon in which cancer cells are able to evade destruction by the immune system, leading to unrestricted growth and progression of the tumor. This term is primarily used in the field of immunology and oncology to describe the ability of cancer cells to avoid recognition and destruction by immune cells, such as T cells and natural killer cells.
When the immune system is functioning optimally, it can identify and eliminate cancer cells through a process known as immune surveillance. However, in many cases, tumor cells develop mechanisms to evade this immune surveillance. Tumor escape can occur through various mechanisms, such as downregulating the expression of molecules involved in antigen presentation, activating immune checkpoint pathways that inhibit immune responses, or secreting immunosuppressive molecules.
The consequences of tumor escape can be detrimental, as it allows cancer cells to continue growing and accumulating genetic alterations, leading to tumor progression and metastasis. Furthermore, tumor escape can render immunotherapies, such as immune checkpoint inhibitors, ineffective, as the cancer cells have developed mechanisms to circumvent immune attack.
Understanding the mechanisms of tumor escape is crucial in developing more effective immunotherapies and strategies to counteract its effects. Ongoing research aims to identify and target key pathways involved in tumor escape, with the goal of enhancing the immune system's ability to recognize and eliminate cancer cells.
Common Misspellings for TUMOR ESCAPE
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Etymology of TUMOR ESCAPE
The etymology of the term "Tumor Escape" can be understood by breaking down the individual words.
1. Tumor: The word "tumor" comes from the Latin word "tumor", which means "a swelling" or "an abnormal growth". This Latin term is derived from the verb "tumere", meaning "to swell".
2. Escape: The word "escape" originates from the Old French word "escaper", which means "to flee" or "to run away". It can be traced back to the Vulgar Latin word "excappare", a combination of the Latin prefix "ex-" (meaning "out") and "cappa" (meaning "cloak").
In the context of cancer research, "tumor escape" refers to the ability of cancer cells to evade or resist destruction by the immune system.
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