CARBAMOYLPHOSPHATE SYNTHETASE II Meaning and
Definition
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Carbamoylphosphate synthetase II (CPS II) is an enzyme that plays a vital role in the biosynthesis of pyrimidine nucleotides, which are crucial building blocks of DNA and RNA molecules. CPS II is primarily found in the cytoplasm of cells and is responsible for catalyzing the stepwise production of carbamoyl phosphate, an essential precursor in nucleotide synthesis.
The enzyme CPS II consists of three subunits: a glutamine amidotransferase subunit (CPS II-A), a large catalytic subunit (CPS II-B), and a small regulatory subunit (CPS II-C). The CPS II-A subunit binds to glutamine and hydrolyzes it to produce glutamate and ammonia. The released ammonia is then utilized by CPS II-B, along with carbon dioxide and two molecules of ATP, to generate carbamoyl phosphate. Lastly, CPS II-C serves as a regulatory subunit that modulates the activity of the enzyme complex.
CPS II is a highly regulated enzyme due to its importance in nucleotide biosynthesis, which is closely linked to cell growth and proliferation. The enzyme's activity is regulated at multiple levels, including feedback inhibition by the end products of the pathway, nucleotide availability, and phosphorylation by protein kinases.
Alterations or dysregulation of CPS II activity have been associated with various diseases, including cancer, metabolic disorders, and neurological disorders. Consequently, CPS II has become a potential target for developing therapeutic interventions aimed at modulating nucleotide metabolism and controlling cell growth in certain pathological conditions.
Common Misspellings for CARBAMOYLPHOSPHATE SYNTHETASE II
- xarbamoylphosphate synthetase ii
- varbamoylphosphate synthetase ii
- farbamoylphosphate synthetase ii
- darbamoylphosphate synthetase ii
- czrbamoylphosphate synthetase ii
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- cwrbamoylphosphate synthetase ii
- cqrbamoylphosphate synthetase ii
- caebamoylphosphate synthetase ii
- cadbamoylphosphate synthetase ii
- cafbamoylphosphate synthetase ii
- catbamoylphosphate synthetase ii
- ca5bamoylphosphate synthetase ii
- ca4bamoylphosphate synthetase ii
- carvamoylphosphate synthetase ii
- carnamoylphosphate synthetase ii
- carhamoylphosphate synthetase ii
- cargamoylphosphate synthetase ii
- carbzmoylphosphate synthetase ii
- carbsmoylphosphate synthetase ii
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