CARBAMYL PHOSPHATE SYNTHASE II Meaning and
Definition
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Carbamyl Phosphate Synthase II (CPSII) is an enzyme that plays a crucial role in the biosynthesis of pyrimidine nucleotides, which are essential components of DNA and RNA molecules. CPSII is an integral part of the de novo pyrimidine synthesis pathway, which is responsible for the production of pyrimidine nucleotides from simple precursor molecules.
CPSII catalyzes the first committed step of this pathway, which involves the formation of carbamyl phosphate. Carbamyl phosphate serves as a critical intermediate in the subsequent steps of pyrimidine synthesis. CPSII accomplishes this process by condensing bicarbonate with glutamine, producing carbamyl phosphate and glutamate as byproducts.
The enzyme CPSII is typically found as a multimeric protein complex consisting of several subunits, known for their unique architectural arrangement. This complex assembly contributes to the stability and functional activity of CPSII. It has been extensively studied in various organisms, including bacteria, plants, and animals, due to its central importance in cellular metabolism.
Mutations or deficiencies in CPSII can lead to severe disturbances in pyrimidine metabolism, resulting in various disorders such as orotic aciduria and hereditary pyrimidine 5'-nucleotidase deficiency. Insights into CPSII's structure and function have provided valuable information for the development of therapeutic interventions to treat these disorders.
Common Misspellings for CARBAMYL PHOSPHATE SYNTHASE II
- xarbamyl phosphate synthase ii
- varbamyl phosphate synthase ii
- farbamyl phosphate synthase ii
- darbamyl phosphate synthase ii
- czrbamyl phosphate synthase ii
- csrbamyl phosphate synthase ii
- cwrbamyl phosphate synthase ii
- cqrbamyl phosphate synthase ii
- caebamyl phosphate synthase ii
- cadbamyl phosphate synthase ii
- cafbamyl phosphate synthase ii
- catbamyl phosphate synthase ii
- ca5bamyl phosphate synthase ii
- ca4bamyl phosphate synthase ii
- carvamyl phosphate synthase ii
- carnamyl phosphate synthase ii
- carhamyl phosphate synthase ii
- cargamyl phosphate synthase ii
- carbzmyl phosphate synthase ii
- carbsmyl phosphate synthase ii
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